地高辛对全因死亡率影响的荟萃分析

Effect of Digoxin on the rate of all-cause mortality: A meta-analysis

目的:荟萃分析地高辛对全因死亡率的影响。方法:收集Medline以及Cochrane数据文献,通过I^2统计量进行异质性检验,用随机效应模型分析地高辛对全因死亡的风险,得到合并效应指标风险比及其95%可信区间。结果:最终纳入文献10篇,总样本量24 865人,地高辛组的全因死亡率风险与对照组并无明显差异(HR1.04,95%CI 0.85~1.28,P=0.68)。结论:临床应用中地高辛并未显著升高全因死亡率。

Objective：To investigate the effect of Digoxin on rate of all-cause mortality by meta-analysis. Methods：The articles were collected from Medline and Cochrane databases. Heterogeneity was analyzed by I2 statistics. The risk of Digoxin on all-cause mortality was analyzed by random effect model to give the hazard ratio （ HR） of combined effect indicators and its 95% confidence interval. Results：Ten studies were included finally, with a total sample size of 24865. There was no significant difference in the risk of all-cause mortality between the Digoxin group and the control group （HR1.04,95% CI 0.85～1.28,P=0.68）. Conclusion：Use of Digoxin in clinical practice does not significantly increase the all-cause mortality.