胡椒酰胺类生物碱的核磁共振谱学特征

NMR Characteristics of Piper Amides

胡椒酰胺类生物碱是胡椒属植物的主要化学成分,结构类型多样,活性显著。自1939年首次报道以来,胡椒酰胺类生物碱一直是研究热点之一。迄今为止,已经从胡椒属植物中分离鉴定了胡椒酰胺类化合物200多个,主要涉及异丙基类、哌啶类、吡咯类等化学结构类型,且具有抗虫、抗菌、抗抑郁等生物活性。本文以胡椒属植物黄花胡椒(Piper flaviflorum)中分离得到的酰胺生物碱为例,探讨胡椒酰胺类生物碱在应用核磁共振波谱进行结构鉴定的规律。

Piper amides ,with structural diversity and potential biological activities, are one of the main chemical compo- nents of Piper app.. Since the first reported amide in 1939 ,piper amides have been one of the hot spots in natural prod- ucts and medicinal chemistry. To date, more than 200 piper amides have been published, including isobutyl, pyrrolidine, piperidine types, etc. These amides showed insecticidal, antibacterial and antidepressive properties. Herein, the piper am- ides from P.flaviflorum were taken as an example to conclude the rule for structural determination of amide alkaloids by NMR data.