摘要
目的系统评价核素MPI参数(SRS、SSS及其差值SDS和LVEF)对冠心病患者远期预后评估的临床价值。方法计算机辅以人工检索Medline、EMbase、Cochrane、知网、万方、维普等数据库关于MPI评价冠心病患者远期预后公开发表的文献,检索期间为2003年1月至2015年1月。按纳入和排除标准筛选文献,提取数据,采用Revman5.3软件进行Meta分析。应用Stata12.0软件绘制倒漏斗图,Begg’s检验进一步判定发表偏倚的可能性。结果共纳入11个研究,11634例患者。Meta分析结果显示:SRS[风险比(nn)=1.14,95%CI:1.11~1.18;z=8.53,P〈0.01]、SSS(HR=1.05,95%C1:1.05-1.23:z=2.34,P=0.02)、SDS(HR=1.14,95%CI:1.01—1.10;z=3.07,P:0.002)和LVEF(HR:0.95,95%CI:0.93~0.97;z=4.53,P〈0.01)评价冠心病患者远期预后有统计学意义。结论核素MPI功能参数评价冠心病患者远期预后有较高的临床价值。
Objective To analyze multiple functional parameters of radionuclide MPI ( SRS, SSS, SDS and LVEF) in order to evaluate the long-term prognosis in patients with coronary heart disease (CHD). Methods The published articles on MPI for long-term prognosis in patients with CHD were searched in Medline, the Excerpta Medica Database (EMbase), Cochrane and China National Knowledge Infrastructure (CNKI) , Wangfang Database, Vip Database from January 2003 to January 2015 with inclusion and exclu- sion criteria. The meta-analysis was conducted using RevMan 5.3 software. Stata 12.0 software was used to draw the funnel plot and to determine the possibility of publication bias by Begg's test. Results A total of 11 studies and 11 634 patients were ultimately included. The meta-analysis indicated that the SRS (hazard ratio (HR)= 1.14, 95% CI: 1.11-1.18; z=8.53, P〈0.01), SSS(HR= 1.05, 95% CI: 1.05-1.23; z=2.34, P= 0.02), SDS(HR=1.14, 95% CI: 1.01-1.10; z=3.07, P=O.002) and LVEF (HR=0.95, 95% CI: 0.93- 0. 97 ; z = 4.53, P〈0.01 ) had statistical significance for the prognosis of CHD. Conclusion MPI functional parameters are significantly valuable for the evaluation of long-term prognosis in patients with ariD.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2016年第4期345-349,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging