内消瘰疬丸、异甘草酸镁联合利福喷丁治疗肺结核疗效观察

Neixiao Luoli pills combined magnesium isoglycyrrhizinate and Rifapentine treatment of pulmonary tuberculosis

目的研究内消瘰疬丸、异甘草酸镁注射液联合利福喷丁治疗肺结核的临床疗效。方法选择在我院就诊的86例肺结核患者作为研究对象,随机分为治疗组与对照组,各43例。对照组给予2HZE/4H治疗方案(E:乙胺丁醇0.75 g/d;H:异烟肼0.3 g/d;Z:吡嗪酰胺1.5 g/d,分3次口服),同时给予利福喷丁及异甘草酸镁注射液治疗;治疗组在对照组治疗基础上给予内消瘰疬丸口服。治疗持续6个月。比较2组临床疗效、病灶吸收、痰涂片转阴、空洞闭合及咯血情况。结果治疗组总有效率为97.7%,明显高于对照组的86.1%;治疗组痰涂片转阴率(83.7%)、病灶吸收率(76.7%)、空洞闭合率(92.6%)、咯血总有效率(93.1%)均明显高于对照组;治疗组肝功能损害,严重胃肠道反应及白细胞减少等不良反应发生率均明显低于对照组。结论内消瘰疬丸、异甘草酸镁联合利福喷丁治疗肺结核,能明显改善临床症状,提高痰涂片转阴率、病灶吸收率、空洞闭合率及咯血总有效率。

Objective To explore the curative effect of neixiao luoli pills combined magnesium isoglycyrrhizinate and rifapentine on pulmonary tuberculosis.Methods The 86 cases of COPD with PTB patients in our hospital were divided into the control group （43 cases） and the treatment group （43 cases） by a randomized way.The control group was given regular treatment,such like antiasthma and anti-inflammation,2HRZE/4HR antituberculosis therapy （E：0.75 g/d ethambutol;H：0.3 g/d isoniazid;Z：1.5 g/d pyrazinamide,points three oral）,magnesium isoglycyrrhizinate and rifapentine treatment either.The treatment group was given Neixiao Luoli pills on the basis of control group.The observation lasted for 6 months and clinical effect,foci absorption,void closure,sputum negative rate were compared between two groups.Results There showed a better efficacy in clinical effect,foci absorption（76.7％）,void closure （92.6％）,sputum negative rate （83.7％） and Haemoptysis total effective rate （93.1％） in the treatment group 97.7％ than the control group 86.1％.Conclusion The Neixiao Luoli pills combined magnesium isoglycyrrhizinate and rifapentine on pulmonary tuberculosis is affirmative and significantly improve the clinical symptoms,increase the rate of sputum smear overcast,foci absorption,void closureand hemoptysis total effective rate.