经皮瘤内注射长春瑞滨碘油乳剂治疗兔VX2瘤的实验研究

Percutaneous intratumoral injection of lipiodol emulsion of vinorelbine for rabbits with VX2 tumor:an experimental study

目的探讨经皮穿刺瘤内注射长春瑞滨碘油乳剂治疗兔VX2肿瘤的疗效。方法建立18只兔VX2肿瘤模型,随机分为3组:长春瑞滨碘油乳剂组8只(A组),单纯长春瑞滨溶液组8只(B组),空白对照组2只(C组)。在超声引导下经皮瘤内注药后的第4天行肿瘤超声造影,计算超声造影及大体标本的肿瘤坏死率,并行肿瘤组织病理检查。结果 A、B、C 3组的超声造影肿瘤肿瘤坏死率分别为64.7%、29.8%、1.7%,大体肿瘤坏死率分别为57.6%、28.2%、1.6%。A组超声造影见肿瘤大部分无增强,病理检查见肿瘤广泛坏死。结论经皮瘤内注射长春瑞滨碘油乳剂治疗兔VX2肿瘤具有良好疗效。

Objective To evaluate the curative effect of intratumoral injection of lipiodol emulsion of vinorelbine in treating VX2 tumors of experimental rabbits. Methods The rabbit models with VX2 tumor were established in 18 experimental rabbits, which were randomly divided into three groups： group A （n = 8, using vinorelbine-lipiodol emulsion） , group B （n= 8, simply using vinorelbine solution） and group C （n= 2, used as blank control group）. At the fourth day after ultrasound-guided intratumoral injection, contrast-enhanced uhrasonography （CEUS） was performed to determine the tumor necrosis rate （TNR）, and the TNR of gross specimen was also measured. The tumor specimens were sent for pathological examinations. Results The tumor necrosis rates measured by CEUS of group A, group B and group C were 64.7%, 29.8% and 1.7%, respectively, The tumor necrosis rates measured on gross specimens of group A, group B and group C were 57.6%, 29.2% and 1.6%, respectively. In group A, CEUS revealed that most tumor tissues showed no enhancement, and pathological examination demonstrated extensive tumor necrosis. Conclusion For VX2 tumors of experimental rabbits, intratumoral injection of lipiodol emulsion of vinorelbine has excellent curative effect.