小剂量尿激酶溶栓联合抗凝治疗中危肺栓塞并下肢深静脉血栓的效果观察

Effect of Low Dose of Urokinase Thrombolysis Combined With Anticoagulant Therapy on the Risk of Pulmonary Embolism and Deep Vein Thrombosis of Lower Extremity

目的观察小剂量尿激酶溶栓联合抗凝治疗中危肺栓塞并下肢深静脉血栓的效果。方法回顾性分析已选定的208例中危肺栓塞并下肢深静脉血栓患者临床资料,根据治疗时不同方案分为对照组与研究组,对照组100例予以抗凝治疗,研究组108例联合小剂量尿激酶溶栓,对比两组治疗前后肺功能指标变化及并发症情况。结果两组肺功能指标均显著改善,且研究组改善幅度比对照组大(P<0.05)。结论中危PE并DVT行小剂量尿激酶溶栓联合抗凝治疗可有效改善患者肺功能,且安全性高。

Objective To observe the effect of low dose of urokinase thrombolysis combined with anticoagulant therapy on the risk of pulmonary embolism and deep vein thrombosis in lower extremity. Methods The clinical data of 208 patients with acute pulmonary embolism and deep venous thrombosis of lower extremity were analyzed retrospectively, according to the treatment of different scheme, the patients were divided into control group and study group, control group 100 cases were treated with anticoagulant therapy, study group 108 cases combined with small dose of urokinase thrombolysis, compared with the two groups before and after the treatment of pulmonary function index changes and complications. Results The lung function indexes of the two groups were significantly improved, and the improvement rate of the study group was larger than that of the control group（P0.05）. Conclusion The risk of PE and DVT small dose of urokinase thrombolysis combined with anticoagulant therapy can effectively improve the patients with pulmonary function, and the safety is high.