红细胞计数变化与代谢综合征及其组分的关联性研究

Association study between metabolic syndrome and red blood cell count changes

目的探讨红细胞计数(RBC)与代谢综合征(metabolic syndrome,Met S)及其组分的关联。方法选取北京市三所医院2012年体检人群作为研究对象,采用Spearman相关分析研究RBC与Met S相关组分之间的关联性,采用多因素logistic回归分析随RBC水平升高Met S患病风险的变化。结果本研究共纳入3 773人。在Spearman两变量相关分析和控制了年龄及Met S其他组分后的偏相关分析中,RBC与高密度脂蛋白胆固醇呈负相关(P<0.05),与Met S其他组分均呈正相关(P<0.05);多因素logistic回归显示,RBC水平的升高与Met S发病风险增加呈正相关。结论 RBC越高者检出Met S的风险越高,RBC与Met S及其组分之间存在一定相关性,可作为Met S发生的一个关键指标。

To investigate the relationship between red blood cell （RBC） and metabolic syndrome （MetS） with its related factors. Methods Participants were enrolled from three hospitals in Beijing in 2012. Spearman correlation analysis was used to explore the association between RBC and MetS, and the logistic regression analysis was performed to assess the changing of risk factors of developing MetS. Results A total of 3 773 participants were ertrolled. Related MetS factors BMI, systolic blood pressure, diastolic blood pressure, fasting blood glucose level, triglyceride were positively correlated （P 〈 0.05） with RBC. Spearman＇ s correlation analysis showed that high density lipoprotein was negatively correlated （P 〈 0.05） with RBC. Multiple logistic regression analysis showed that the increase of RBC level was positively correlated with the risk of MetS after adjusted for age, sex, serum cholesterol level. Conclusion People with higher RBC value have a higher risk of developing MetS. RBC and MetS with its components are related, and it can be used as a key indicator of MetS.