硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果

Clinical effect of magnesium sulfate combined with nifedipine in hypertensive disorder complicating pregnancy

目的探讨硫酸镁联合硝苯地平治疗妊娠期高血压疾病（hypertensive disorder complicating pregnancy,HDCP）患者的临床效果。方法本研究采用回顾性研究方法,选取2011年1月～2015年7月中国人民解放军第一五四中心医院妇产科收治的116例HDCP患者,其中常规组62例予常规支持治疗＋硫酸镁治疗,联合组54例予常规支持治疗＋硫酸镁＋硝苯地平治疗,2组患者均连续治疗5 d,对比临床效果。结果治疗后,联合组患者的收缩压、舒张压、24 h尿蛋白定量、随机尿蛋白/肌酐值、血清同型半胱胺酸（homocysteine,Hcy）、C反应蛋白（CRP）均显著低于常规组（P〈0.05）;治疗后,联合组和常规组患者宫缩乏力、新生儿窒息、胎儿窘迫、产后出血的发生率差异无统计学意义,联合组患者的剖宫产率50.00%显著低于常规组的68.25%（P〈0.05）。结论硫酸镁联合硝苯地平治疗HDCP患者具有更好的降压效果,同时不会增加胎儿不良分娩结局的发生率并可显著降低患者的剖宫产率。

Objective To investigate the clinical effect of magnesium sulfate combined with nifedipine in the treatment of patients with pregnancy induced hypertension（ HDCP）. Methods Retrospective study was used in this study and 116 patients with HDCP from January 2013 to July 2015 in department of obstetrics and gynecology from our hospital were divided into two groups,including routine group of 62 patients who received routine treatment ＋ magnesium sulfate） and combination group of 54 patients who received routine treatment ＋ magnesium sulphate ＋ nifedipine. The clinical effect was analyzed after five days＇ continuous treatment. Results The systolic blood pressure,diastolic blood pressure,24 h urinary protein,random urine protein / creatinine,serum homocysteine（ Hcy） and CRP values in combination group were lower than routine group（ P〈0. 05）. There were no statistical difference in maternal uterine inertia,neonatal asphyxia,fetal distress,postpartum hemorrhage rate between the two groups after the treatment. But the rate of cesarean section in the combination group（ 50. 00%） was significantly lower than that in the routine group（ 68. 25%）（ P〈0. 05）. Conclusion Magnesium sulfate combined with nifedipine in the treatment of patients with HDCP had better antihypertensive effect,and would not increase fetal adverse birth outcomes incidence and significantly reduce the rate of cesarean section.