厄贝沙坦氢氯噻嗪与坎地沙坦西酯对高血压患者炎症因子及临床疗效的比较

Comparison of clinical curative effect and inflammation factors between irbesartan hydrochlorothiazide and candesartan cilexetil in hypertension

目的比较厄贝沙坦氢氯噻嗪与坎地沙坦西酯对高血压患者血清炎症因子及临床疗效的影响。方法选取2014年6月～2015年10月收入院的高血压病患者86例,根据随机数字表法随机分为2组：对照组43例予坎地沙坦西酯治疗;实验组43例予厄贝沙坦氢氯噻嗪治疗,检测2组患者血压、C反应蛋白（CRP）、白介素6（IL-6）、一氧化氮（NO）等指标的变化,评价2种治疗方法的临床疗效。结果实验组经治疗后收缩压、舒张压水平明显低于对照组（P〈0.05）;实验组血清CRP、IL-6水平明显低于对照组,NO水平明显高于对照组（P〈0.05）。结论厄贝沙坦氢氯噻嗪对高血压病患者具有较好的临床疗效,且安全性较高。

Objective To investigate the comparison of clinical curative effect and inflammation factors between irbesartan hydrochlorothiazide and candesartan cilexetil in the treatment of patients with hypertension. Methods A total of 86 patients with hypertension in our hospital from June 2014 to October 2015 were collected and randomly divided into two groups,43 cases in the control group were treated by candesartan cilexetil,43 cases in the experimental group were treated by irbesartan hydrochlorothiazide. The blood pressure,CRP,IL-6 and NO indexes were detected in the two groups and the clinical curative effect of the two groups was compared. Results The systolic pressure and diastolic pressure levels in the experimental group were significantly lower than the control group（ P〈0. 05）; the serum CRP,IL-6 levels in experimental group were significantly lower than the control group,the NO level was significantly higher than the control group（ P〈0. 05）. Conclusion Irbesartan hydrochlorothiazide in the treatment of patients with hypertension has a better clinical curative effect,and higher security.