加减柴胡桂枝干姜汤在偏头痛肝郁脾虚证中的临床应用

Clinical application of modified Chaihuguizhi dried ginger soup in treatment of liver stagnation and spleen deficiency migraine

目的探讨偏头痛肝郁脾虚证应用加减柴胡桂枝干姜汤治疗的临床效果。方法选取浙江省杭州市萧山区第一人民医院中医科2014年6月～2016年2月收治的102例偏头痛肝郁脾虚证患者,随机均分为2组。对照组：采取常规西药治疗;观察组：给予加减柴胡桂枝干姜汤治疗。记录比较2组临床疗效,治疗前后伴随症状、持续时间、疼痛程度、发作次数等症状量化评分及血浆比粘度、全血比粘度、红细胞比容（hematocrit,HCT）、血清5-羟色胺（5-hydroxytryptamine,5-HT）水平,治疗期间用药安全性。结果观察组总有效率为92.16%与对照组76.47%相比,显著较高（P〈0.05）;2组治疗后伴随症状、持续时间、疼痛程度及发作次数与治疗前比较均显著改善（P〈0.01）,且观察组下降幅度更为显著（P〈0.01）;与治疗前比较,治疗后2组血浆比粘度、全血比粘度、HCT及5-HT水平均显著改善（P〈0.01）,且观察组更优（P〈0.01）。结论偏头痛肝郁脾虚证应用加减柴胡桂枝干姜汤治疗更有利于缓解临床症状,疗效显著,安全可靠。

Objective To explore the clinical effect of the application of modified Chaihuguizhi dried ginger soup in the treatment of liver stagnation and spleen deficiency migraine. Methods 102 cases of liver stagnation and spleen deficiency migraine patients treated in our hospital from June 2014 to February 2016 were selected and randomly divided into two groups. The control group were given conventional western medicine; the observation group were given modified Chaihuguizhi dried ginger soup. The clinical curative effect,accompanied symptoms before and after the treatment,duration,degree of pain,the symptom scores of episode,and plasma specific viscosity,whole blood viscosity,hematocrit of red blood cell（ HCT）,serum 5-hydroxytryptamine（ 5-HT） level,medication safety during the treatment of the groups were recorded and compared. Results The total effective rate of the observation group（ 92. 16%） was significantly higher than the control group（ 76. 47%）（ P〈0. 05）; accompanied symptoms,duration,degree of pain and the number of attacks of the two groups after the treatment,compared with those before the treatment,improved significantly（ P〈0. 01）,and the decrease degree of the observation group was more significant（ P〈0. 01）; compared with those before the treatment,the plasma specific viscosity,blood viscosity,HCT and 5-HT levels improved significantly in the two groups after the treatment（ P〈0. 01）,and the observation group was better（ P〈0. 01）. Conclusion The application of Chaihuguizhi dried ginger soup in the treatment of migraine of liver stagnation and spleen deficiency is more conducive to ease the clinical symptoms,with more remarkable curative effect,safely and reliably,which has high clinical reference value.