黄藤素序贯联合运动疗法对盆腔炎患者血清炎性指标的影响及其临床效果

Effect of palmatine sequential combination of exercise therapy on serum inflammatory markers in pelvic inflammation and its clinical effect

目的探讨黄藤素序贯疗法联合运动疗法对盆腔炎患者的治疗效果及对血清炎性指标的影响。方法选取2015年1月～2016年1月南昌大学第四附属医院妇科收治的120例盆腔炎患者采用随机数字表法分为试验组和对照组各60例,2组患者均给予环丙沙星、替硝唑等基础治疗,试验组同时给予黄藤素联合运动疗法治疗,疗程4 w。结果治疗前,试验组和对照组患者的血清白介素1β（IL-1β）、IL-6、肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）水平差异均无统计学意义;治疗后,试验组患者的血清IL-1β、IL-6、TNF-α、CRP水平显著低于对照组患者（P〈0.05）;治疗后,试验组患者的腹隐痛、腰骶部酸痛、带下量多、白带色白质稀、头晕耳鸣、经量多或少积分显著低于对照组患者（P〈0.05）;试验组患者治疗总有效率96.67%显著高于对照组的83.33%,差异具有统计学意义（P〈0.05）。结论黄藤素序贯疗法联合运动疗法能够进一步改善患者的炎症反应、中医证候,从而提高临床治疗效果。

Objective To explore the effect of palmatine sequential therapy combined with exercise therapy on serum inflammatory markers in the treatment of patients with pelvic inflammatory disease. Methods 120 cases of pelvic inflammatory disease from January 2015 to January 2016 admitted to our hospital and randomly divided into experimental group and control group（ 60 cases of each group）. The two groups of patients were given basic treatment of ciprofloxacin and tinidazole,while experimental group were given fibrauretine combined with exercise therapy,with a course of 4 weeks.Results Before treatment,there was no significant difference in serum IL-1β,IL-6,TNF-α and CRP levels between two groups. After treatment,the above indicators in experimental group were lower than those in control group（ P〈0. 05）. After treatment,the scores of abdominal pain,lumbosacral pain,vaginal discharge volume,white and thin leucorrhea,dizziness and tinnitus,menometrorrhagia or hypomenorrhea were significantly lower in experimental group than those in control group（ P〈0. 05）. The total effective rate of experimental group was 96. 67%,which was significantly higher than 83. 33% in control group,the difference was statistically significant（ P〈0. 05）. Conclusion Palmatine sequential therapy combined with exercise therapy could further improve the patient＇s inflammatory response syndromes,thereby improving clinical outcomes.