摘要
目的中枢神经系统创伤、缺血、出血卒中均经历相同病理损害,在相应的动物模型中,组蛋白去乙酰化酶抑制剂表现出广泛的神经保护作用,有望成为一类新的潜在治疗剂,但其具体机制尚不明确。现对组蛋白去乙酰化酶抑制剂的神经保护作用研究进展作一综述,以提高人们组蛋白去乙酰化酶抑制剂的认识,为今后开展相关研究提供理论基础。
Objective Central nervous system trauma,ischemia,hemorrhagic stroke were all experienced the same pathological damage,in related animal experiments,histone deacetylase inhibitors have a wide range of neuroprotective effect,it is expected to become a new class of potential therapeutic agents. However,the specific mechanism is not clear. In this paper,the research progress of neuroprotective effect of histone deacetylase inhibitors is reviewed,in order to improve recognition of histone deacetylase inhibitors and provide foundation for futher study.
出处
《中国生化药物杂志》
CAS
2016年第6期200-203,共4页
Chinese Journal of Biochemical Pharmaceutics
基金
广西壮族自治区卫生和计划生育委员会厅自筹经费科研课题(Z2015151)
