血清金属蛋白酶-9水平对冠心病患者PCI术后再狭窄的影响

Relationship between the serum levels of matrix metalloproteinase-9 and in-stent restenosis

目的探讨血清金属蛋白酶-9（MMP-9）水平与冠心病经皮冠状动脉介入（PCI）术后再狭窄的关系。方法选择2012年1月至2013年8月因冠心病首次行PCI治疗的患者200例,其中男性133例,女性67例,年龄50~75（64.5±12.6）岁。检测患者术前和术后24h血清MMP-9水平。依据冠状动脉造影复查结果将患者分为再狭窄组及无再狭窄组。比较两组患者术前及术后MMP-9水平。结果再狭窄组17例,无再狭窄组183例。两组患者临床资料、造影和PCI结果及术前MMP-9水平差异无统计学意义,再狭窄组术后MMP-9抗原、MMP-9活性[（1 135.26±402.53）、（55.23±27.12）ng/ml]均高于无再狭窄组[（698.12±220.24）、（24.73±12.36）ng/ml],差异均有统计学意义（t=4.468、5.532,均P〈0.05）。结论 PCI术后支架再狭窄患者术后血清MMP-9水平升高。

Objective To explore the relationship between the serum matrix metalloproteinase-9 （MMP-9） and in-stent restenosis after percutaneous coronary intervention （PCI）. Methods 200 patients （133 male, 67 female, aged from 50 to 75 years） underwent first PCI from Jan 2012 to Aug 2013 were enrolled and divided into re-stenosis group and no-restenosis group based on the results of follow up angiography. Serum MMP-9 was measured before and 24 hours later after PCI and compared between the two groups. Results There were 17 patients in re-stenosis group and 183 patients in no-restenosis group. Clinical data, angiographic and PCI results and serum MMP-9 before PCI were not significant difference between two groups. Postoperative MMP-9 antibody and MMP-9 activity were significantly higher in re-stenosis group[（1 135.26 ± 402.53）, （55.23 ± 27.12）ng/ml] than in no-restenosis group [（698.12 ± 220.24）, （24.73± 12.36） ng/ml]（all P〈0.05）. Conclusion Postoperative serum MMP-9 level increases in patients with in-stent restenosis after PCI.