摘要
目的研究松香对小鼠皮肤癌的防治效果。方法采用紫外线照射和二甲基苯蒽外涂诱导致小鼠皮肤癌动物模型,同时以松香溶液涂抹皮肤。常规HE染色病理检查和免疫组织化学染色观察小鼠背部皮肤变化过程,分析皮肤组织中上皮角蛋白CK10、CK5/6表达强度,评价松香对小鼠皮肤癌的药效。结果松香给药组小鼠皮肤上皮角蛋白表达较模型组显著降低,松香对小鼠皮肤癌有显著治疗作用。结论松香具有很好的抗皮肤癌的作用。
OBJECTIVE To study the pharmacodynamic effect of rosin on mice skin cancer. METHODS Skin cancer mice model was caused by the combination of UVC and DMBA, rosin was meanwhile intervened. The histopathology features of skin dyed HE staining and immunohistochemical staining were observed to explore tumor formation and skin morphological alteration, and CK10 and CK5/6 were examined. RESULTS Rosin treatment had an obvious effect on experimental mice, and decreasing the expression of CK10 and CK5/6 might be one of the possible mechanisms of the therapy. CONCLUSION Rosin has a good effect on skin cancer.
出处
《中国现代应用药学》
CAS
CSCD
2016年第8期997-1000,共4页
Chinese Journal of Modern Applied Pharmacy
基金
江苏高校优势学科建设工程资助项目(YSKX-2014)
关键词
松香
皮肤癌
上皮角蛋白
rosin
sin cancer
eithelial keratin
