水飞蓟宾自乳化制剂对CCl_4所致肝损伤的保护作用

Protective Effects of Silybin Self-emulsifying Drug Delivery Systems on Acute Liver Injury Induced by CCl_4

目的探讨水飞蓟宾自乳化制剂对CCl4所致急性肝损伤的保护作用。方法以CCl4所致小鼠急性肝损伤为模型,以生理盐水为阴性对照,以联苯双酯为阳性对照,以水飞蓟宾混悬剂为参比,以血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝脏中谷胱甘肽过氧化物酶(GSH-PX)活性及肝脏病理组织切片检查为指标,对比研究水飞蓟宾自乳化制剂对CCl4所致急性肝损伤的保护作用。结果水飞蓟宾自乳化制剂能显著的抑制CCl4所致的血清ALT和AST活性升高,使肝脏中的GSH-PX维持在正常水平,保护肝脏并避免其发生严重病变。结论水飞蓟宾自乳化制剂对CCl4所致急性肝损伤有保护作用。

OBJECTIVE To explore the protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl4. METHODS Saline and bifendate were selected as negative and positive control, respectively. The protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl4 was evaluated by the levels of ALT and AST in plasma, glutathione peroxidase in liver and liver histopathology, and compared with silybin suspension. RESULTS Silybin self-emulsifying drug delivery systems inhibited the increase of the ALT and AST in serum markedly, maintained the normal level of GSH-PX in liver and protect liver from lesion. CONCLUSION Silybin self-emulsifying drug delivery system has protectived effect on acute liver injury induced by CCl4.