孕激素受体膜元件1在颗粒细胞中的功能及女性生殖中的作用被引量：2

Role of progesterone receptor membrane component 1 in granulosa cells function and female fertility

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摘要孕激素受体膜组件1(PGRMC1)是近年来新发现的特殊受体,属于膜相关的孕激素受体(MAPR)蛋白家族。PGRMC1介导孕酮(P4)的抗有丝分裂和抗凋亡作用,并参与了颗粒细胞合成甾体激素的过程。在临床上,PGRMC1的异常表达与卵巢早衰(POF)及多囊卵巢综合征(PCOS)相关。本文就PGRMC1对颗粒细胞功能的影响、与卵泡发育的关系以及在人类生殖中的作用展开综述。 Progesterone receptor membrane component 1 （PGRMC1）, which belongs to the membrane- related progesterone receptor （MAPR） protein family, has been known as a novel special receptor in recent years. PGRMC 1 mediated progesterone＇s action of anti-mitotic and anti-apoptotic. Moreover, PGRMC 1 is also involved in steroid synthesis of granulosa cells. In the clinic, abnormal PGRMC 1 expression has been proved to be related with premature ovarian failure （POF） and polycystic ovary syndrome （PCOS）. The purpose of this article is to summarize the effect of PGRMC 1 on granulosa cell function, the relationship between PGRMC 1 and follicle development as well as the effect of PGRMC 1 on human reproduction.

作者周丽霞赵烨温晓薇匡延平柴蔚然

机构地区上海交通大学医学院附属第九人民医院辅助生殖科山西医科大学第一医院妇产科山西医科大学生物化学与分子生物学

出处《生殖与避孕》 CAS CSCD 北大核心 2016年第8期613-618,共6页 Reproduction and Contraception

基金上海市科学技术委员会科研计划项目(15411953000,15411964500) 默克雪兰诺中国生殖医学研究基金资助

关键词孕激素受体膜元件1(PGRMC1) 颗粒细胞(GC) 卵泡发育卵巢早衰(POF) 多囊卵巢综合征(PCOS) progesterone receptor membrane component 1 （PGRMC1） granulosa cells （GCs） follicledevelopment premature ovarian failure （POF） polycystic ovary syndrome （PCOS）

分类号 R339.22 [医药卫生—人体生理学]

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