肺发育与相关疾病机制研究进展

Study progress of pathogenesis in lung development and related diseases

肺部疾病是危害新生儿及儿童健康的重大疾病。认识其发病机制，实施有效的预防和精准诊疗是儿科医师面临的重要挑战。研究显示肺发育的缺陷是导致新生儿及儿童肺部疾病和引起疾病易感的重要根源。针对肺发育经历的不同时期，现介绍其影响因素、关键调控分子和肺发育缺陷引起的相关疾病，为临床医师从发育的角度探索肺部疾病机制提供依据和思路。

Pulmonary diseases are seriously harmful to the health of the newborns and children. Understanding the pathogenesis of pulmonary diseases, carrying out effective prevention and accurate diagnosis are challenges for pediatrician. Previous study demonstrated that lung development defects are source of disease susceptibility and closely associated with newborn＇s and ehildren＇s pulmonary diseases. This article will focus on lung development, introducing the impact factor and the key regulatory molecules about lung development and pulmonary development defect related diseases which will provide important insights for clinician to explore the mechanism of pulmonary diseases.