生长抑素联合生植物油治疗肠梗阻的临床研究

Clinical study of somatostatin combined with raw vegetable oil in treat-ment of intestinal obstruction

目的评价生长抑素联合生植物油治疗肠梗阻的临床疗效及不良反应。方法选取铜川市人民医院2012年8月-2015年8月收治的肠梗阻患者364例，随机分为观察组182例，对照组182例。两组均给予以基础疗法为主的非手术治疗，包括胃肠减压，矫正水、电解质紊乱和酸碱失衡，防治感染和中毒，应用镇静剂、解痉剂等治疗；非手术治疗无效或加重，则改为手术治疗。观察组患者均加用生长抑素联合生植物油进行治疗。比较两组患者的疗效、手术治疗率、胃肠减压量、住院时间、不良反应。结果观察组和对照组相比，观察组总有效率明显优于对照组（80．22％vs68．68％，x2=8．58，P〈0．05），手术治疗率明显降低（29．67％vs40．11％，x2=4．37，P〈0．05），胃肠减压量明显减少[（224±171）ml／dvs（543±186）ml／d，t=-21．28，P〈0．05）】,住院时间明显缩短1（6．14±2．04）d vs（10．26±3．12）d，t=-4．78，P〈0．05）]，不良反应无明显增加。结论在基础疗法之上加用生长抑素联合生植物油治疗肠梗阻显效率高，疗效好，不良反应无明显增加，安全性好，值得临床应用、推广。

Objective To evaluate the clinical effects and adverse reaction of somatostatin combined with raw vegetable oil in treatment of intestinal obstruction From Tongchuan City People＇s Hospital were conducted through clinical medication. Methods From August 2012 to August 2015, A total of 364 cases of intestinal obstruction were randomly divided into observation group （ 182 cases） and control group （ 182 cases）. Two groups were treated with the non-surgical treatment based on basic therapy, including gastrointestinal decompression, con＇cctional of water, electrolyte disturbance and acid-base imbalance to prevent infection and toxieation by sedative and spasmo- lytic. The non- surgical treatment was invalid or worse, the surgical treatment wasselected. Additionally, on the ba- sis of non- surgical treatment, somatostatin combined with raw vegetable oil was additional treatment for the obse^va- tion group. The comparison of thecurative effect, surgical treatment rate, gastrointestinal decompression, hospital stays and adverse reaction of two groups was conducted. Results The curative effect of observation group （80.22%）was superior to control group（68.68% ）. Compared to control group, the cases of adverse reaction in observation group was insignificantly increased （X2 = 8.58, P 〈 0.05）. Conversely, the observation group showed lower surgical treatment rate （29.67% vs 40. 11%, X2= 4. 37, P 〈 O. 05 ） , lower gastrointestinal decompression [（224±171） ml/dvs （543±186） ml/d, t= -21.28, P〈0.05）], and less hospital stays [ （6.14±2.04） d vs （ 10.26 ± 3.12） d, t = - 4. 78, P 〈 0. 05） 1- Conclusions The basic therapy and somatostatin combined with raw vegetable oil showed high efficiency, and eases of adverse reaction was insignificantly increased. It was worthy of pronmtion and application.