异甘草酸镁防治乳腺癌化疗所致肝损伤的疗效观察

EFFICACY OF MAGNESIUM ISOGLYCYRRHIZINATE IN THE PREVENTION OF BREAST CANCER CHEMOTHERAPY-INDUCED LIVER INJURY

目的探讨异甘草酸镁防治乳腺癌化疗所致药物性肝损伤的临床应用价值。方法选取河北省唐山市丰润区人民医院2014年4月—2016年4月收治的103例乳腺癌患者,进行回顾性分组研究。103例患者按是否应用预防性保护肝脏治疗方案分为二组。预防应用异甘草酸镁组51例,不加用任何种类的保肝药物的对照组52例。二组乳腺癌患者辅助化疗方案采用EC-T及TC方案,化疗前以及化疗后第二周检测肝功能,比较二组患者由化疗药物导致肝损伤的发生率。结果预防性保护肝脏治疗的患者肝损伤的发生率低于对照组,差异均有统计学意义(P<0.05),采用多因素Logistic回归分析,结果显示未行预防性保护肝脏治疗的患者发生化疗性肝损伤的风险明显增高。结论预防性应用异甘草酸镁保护肝脏治疗可减少乳腺癌患者化疗药物引起的肝损伤的发生,有较高的临床应用价值。

Objective To investigat the clinical value of Isoglycyrrhizinate magnesium on preventing drug- induced liver injury caused by chemotherapy in breast cancer. Methods A total of 103 breast cancer pa- tients were selected from April 2014 to April 2016 in authors hospital for a retrospective study. Patients ac- cording to whether received a prophylactic treatment of liver protection were divided into prophylactic Iso- glycyrrhizinate magnesium group which contains 51 cases and without any kind of hepatoprotective drugs control group which contains 52 cases. Two groups were compared by the chemotherapeutic drug- induced liver injury incidence. Results The preventive treatment of patients on incidence of the chemotherapeutic drug- induced liver injury was much less than the control group, the difference was statistically significant （P〈0. 05）. Multivariate logistic regression analysis showed that the patients did not undergo prophylactic treatment had significantly higher risk of chemotherapy- induced liver injury. Conclusion Prophylactic isoglycyrrhizinate magnesium protecting the liver can reduce the incidence of breast cancer patients with chemotherapy-induced liver injury, there is a high clinical value.