血浆同型半胱氨酸及胱抑素C在急性脑梗死患者中含量变化的分析

Analysis of plasma homocysteine and cystatin C level change in patients with acute cerebral infarction

目的通过对急性脑梗死患者血浆中同型半胱氨酸、胱抑素C含量的测定，探讨两者在急性脑梗死患者血浆中含量的变化。方法选取2014年5月～2015年12月在瓦房店市中心医院神经内科住院治疗的60例脑梗死患者为研究对象（脑梗死组），选取我院体检中心40岁以上无脑血管病史30例健康人为对照组，比较脑梗死组与对照组血浆同型半胱氨酸与胱抑素c水平，脑梗死组患者各型之间以及与对照组血浆同型半胱氨酸、胱抑素C之间的比较．同时分析脑梗死组患者血浆同型半胱氨酸与胱抑素c的相关性。结果脑梗死组与对照组血浆中同型半胱氨酸、胱抑素C水平比较，差异有统计学意义（P〈0．05）；脑梗死组患者各型血浆同型半胱氨酸、胱抑素C之间比较，差异无统计学意义（P〉0．05）；血浆同型半胱氨酸与胱抑素c水平呈正相关。结论血浆同型半胱氨酸和胱抑素c与急性脑梗死的发病密切相关。

Objective To test content of plasma homocysteine and cystatin C in patients with acute cerebral infarction and explore changes both in patients with acute cerebral infarction.Methods From May 2014 to December 2015,60 patients with cerebral infarction hospitalized in department of neurology of Wafangdian central hospital were selected as research objects （cerebral infarction group）,30 healthy people over 40 years old without a history of cerebrovascular disease were selected as control group in our hospital medical center.Plasma homocysteine and cystatin C levels were compared between cerebral infarction group and control group,plasma homocysteine and cystatin C were compared be- tween various types in cerebral infarction group and control group,the correlation between plasma homocysteine and cystatin C in cerebral infarction group was analyzed.Results The difference of plasma homocysteine and cystatin C lev- els was statistically significant （P〈0.05） between cerebral infarction group and control group,plasma homocysteine and cystatin C levels between the various types in cerebral infarction group,the difference was not statistically significant （P〉0.05）;plasma homocysteine was positively correlated with cystatin C levels.Conclusion Plasma homocysteine and cystatin C is closely related with acute cerebral infarction attack.