多重耐药铜绿假单胞菌的感染因素及耐药分析

Infection factors and drug resistance analysis of multi-drug resistant Pseudomonas aeruginosa

目的探讨我院多重耐药铜绿假单胞菌的感染情况和特点，为临床感染控制提供依据。方法采用梅里埃VITEC2-Compact全自动微生物分析系统进行鉴定和药敏试验，对2013年1月～2015年1月临床各种标本分离出的95株多重耐药铜绿假单胞菌的耐药性及临床资料进行分析。结果95例多重耐药铜绿假单胞菌中，来自患者的痰液标本占78．9％（75／95），其次是伤口表面分泌物，占10．5％（10／95）。感染因素与气管插管、深静脉插管、外伤创面等因素有关。药敏结果分析显示，PA对头孢曲松的耐药率已达95．00％以上，对头孢他定的耐药率也已达到36．30％。结论多重耐药铜绿假单胞菌感染与各种侵入性的导管和器械检查有关，因此，临床进行创伤治疗时，必须制定有效的感染控制措施。并对铜绿假单胞菌感染患者进行连续的耐药监测和患者隔离，控制多重耐药铜绿假单胞菌的扩散和流行。

Objective To explore the infection situation and features of multi-drug resistant Pseudomonas aeruginosa in our hospital and to provided basis for clinical infection control.Methods BioMerieux VITEC2-Compact automatic mi- crobiology analysis system was applied to identify and to conduct the drug sensitive test.The drug resistance and clini- cal materials of 95 strains of muhi-drug resistant Pseudomonas aeruginosa separated from clinical samples from Jan uary 2013 to January 2015 were analyzed.Results 78.9% （75/95） of the 95 strains of multi-drug resistant Pseudomonas aeruginosa were separated from sputum samples,followed by secretion of wounds （10.5%,10/95）.Trachea intubation,deep venous cannula,and trauma wound were significant infection factors.Drug sensitivity results showed that the drug resis- tance of ceftriaxone was over 95.00%,and the resistance rate of ceftazidime was 36.30%.Conclusion Infection of multi- drug resistant Pseudomonas aeruginosa is related to various invasive catheters and instrumental examinations.Therefore, in the treatment of trauma,effective infection control measures should be formulated to conduct continuous drug resis- tance monitoring and isolation of those infected with Pseudomonas aeruginosa and to control the spread and prevalence of multi-drug resistant Pseudomonas aeruginosa.