血清胰岛素样生长因子相关指标及白细胞介素与妊娠高血压疾病的关系研究被引量：8

Study of the relationship of serum insulin-like growth factor-related indicators and interleukins with pregnancy-induced hypertension

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摘要目的:探讨血清胰岛素样生长因子相关指标及白细胞介素与妊娠高血压疾病的关系。方法:选择妊娠期高血压患者34例,轻度子痫前期患者27例,重度子痫前期患者18例,健康产妇50例作为研究对象,采集血清并测定胰岛素样生长因子(IGF)-Ⅰ、IGF-Ⅱ、胰岛素样生长因子结合蛋白(IGFBP)-1、白介素(IL)-6、IL-8、IL-18含量,收集胎盘并测定IGF-Ⅰ、IGF-Ⅱ、IGFBP-1、IL-6、IL-8、IL-18含量。结果:妊娠期高血压组、轻度子痫前期组、重度子痫前期组胎盘组织和血清中IGF-Ⅰ、IGF-Ⅱ含量均显著低于健康对照组(P<0.05),IGFBP-1、IL-6、IL-8、IL-18含量均显著高于对照组(P<0.05);血清IGF-Ⅰ、IGF-Ⅱ含量与IL-6、IL-8、IL-18含量呈负相关,血清IGFBP-1含量与IL-6、IL-8、IL-18含量呈正相关。结论:血清IGF-Ⅰ、IGF-Ⅱ含量降低以及IL-6、IL-8、IL-1、IGFBP-1含量升高与妊娠高血压疾病的发生有关,IGF-I、IGF-II含量降低以及IGFBP-1含量升高与白细胞介素含量的升高密切相关。 Objective： To study the relationship of serum insulin-like growth factor-related indicators and interleukins with pregnancy-induced hypertension. Methods： A total of 34 patients with gestational hypertension,27 patients with mild preeclampsia,18 patients with severe preeclampsia and 50 healthy women were selected as the research subjects,serum was collected to determine serum insulin-like growth factor（ IGF）-Ⅰ,IGF-Ⅱ,insulin- like growth factor binding proteins（ IGFBP）-1,interleukin（ IL）-6,IL-8 and IL-18 content,and the placenta was collect to determine IGF-Ⅰ,IGF-Ⅱ,IGFBP-1,IL-6,IL-8 and IL-18 content. Results：IGF-Ⅰ and IGF-Ⅱ levels in placenta tissue and serum of gestational hypertension group,mild preeclampsia group and severe preeclampsia group were significantly lower than those of control group,and IGFBP-1,IL-6,IL-8 and IL-18 levels were significantly higher than those of control group（ P〈0. 05）; serum IGF-Ⅰ and IGF-Ⅱ levels were negatively correlated with IL-6,IL-8 and IL-18 levels,and serum IGFBP-1 level was positively correlated with IL-6,IL-8 and IL-18 levels（ P〈0. 05）. Conclusions： Decreased serum IGF-Ⅰ,IGF-Ⅱ levels and increased serum IGFBP-1,IL-6,IL-8 and IL-18 levels are associated with pregnancy-induced hypertension,and decreased IGF-Ⅰ and IGF-Ⅱ levels and increased IGFBP-1 level are closely related to increased levels of interleukins.

作者米娜瓦尔.艾则孜

机构地区新疆喀什地区第二人民医院妇产科

出处《海南医学院学报》 CAS 2016年第16期1786-1788,1791,共4页 Journal of Hainan Medical University

基金新疆维吾尔自治区科技攻关计划(2012GG2049)~~

关键词妊娠高血压疾病胰岛素样生长因子(IGF) 胰岛素样生长因子结合蛋白(IGFBP) 白细胞介素 Pregnancy-induced hypertension Insulin-like growth factor Insulin-like growth factor-binding protein Interleukin

分类号 R714.2 [医药卫生—妇产科学]

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