强骨胶囊联合鲑鱼降钙素针剂治疗对老年骨质疏松性压缩骨折患者骨密度及骨代谢的影响

Effect of Qianggu Capsule combined with salmon calcitonin injection treatment on bone mineral density and bone metabolism in patients with senile osteoporotic compression fractures

目的:分析强骨胶囊联合鲑鱼降钙素针剂治疗对老年骨质疏松性压缩骨折患者骨密度及骨代谢的影响。方法:92例老年骨质疏松性压缩骨折患者按照随机数表法分为观察组及对照组,各46例,对照组接受单独强骨胶囊治疗,观察组接受强骨胶囊联合鲑鱼降钙素针剂治疗,对比两组骨密度、骨代谢指标及CT相关参数差异。结果:观察组治疗3个疗程及6个疗程后骨密度(BMD)值高于对照组(P<0.05);观察组治疗后血清骨钙素(BGP)、甲状旁腺激素(PTH)值高于对照组,Ⅰ型胶原羧基端前肽(CICP)、Ⅰ型胶原羧基端交联肽(CTX-Ⅰ)值低于对照组,尿液中脱氧胶原吡啶交联(D-Pyr)值低于对照组(P<0.05);观察组治疗后松质骨体积(CV)、CV/MV值高于对照组,髓腔体积(MV)值低于对照组(P<0.05)。结论:强骨胶囊联合鲑鱼降钙素针剂可以抑制老年骨质疏松性压缩骨折患者病情进展,优化骨代谢过程并促进成骨过程,具有积极的临床意义。

Objective： To analyze the effect of Qianggu Capsule combined with salmon calcitonin injection treatment on bone mineral density（ BMD） and bone metabolism in patients with senile osteoporotic compression fractures. Methods： A total of 92 cases of patients with senile osteoporotic compression fractures were divided into observation group and control group（ n = 46） according to random number table; control group received Qianggu Capsule treatment alone,observation group received Qianggu Capsule combined with salmon calcitonin injection treatment,and the differences in bone mineral density,bone metabolism indexes and CT-related parameters were compared between two groups. Results： BMD values of observation group after 3 courses and 6 courses of treatment were significantly higher than those of control group（ P〈0. 05）; serum bone gla protein（ BGP） and parathyroid hormone（ PTH） values of observation group after treatment were significantly higher than those of control group,CICP and CTX-Ⅰ values were significantly lower than those of control group,and urine D-Pyr value was significantly lower than that of control group（ P〈0. 05）; cancellous bone volume（ CV） and CV / marrow cavity volume（ MV） values of observation group after treatment were significantly higher than those of control group,and MV value was significantly lower than that of control group（ P〈0. 05）. Conclusions： Qianggu Capsule combined with salmon calcitonin injection can inhibit the disease progression in patients with senile osteoporotic compression fractures,optimize bone metabolism and promote osteogenesis,and it has positive clinical significance.