热处理对“纤-膜”结构输尿管支架管降解行为的影响

Effect of Heat-Treatment on the Degradation of Ureteral Stent with“Fiber-Film”Structure

采用3种热工艺处理聚乙交酯(PGA)和聚乙交酯丙交酯(PGLA)纤维编织成的支架管,形成"纤-膜"及全纤维结构输尿管支架管,于人体尿液和模拟尿液环境中进行降解试验,并对降解过程中支架管的力学性能和外观形态进行评价.试验结果表明:支架管降解随热处理温度的升高而加快;高温热处理可加大双组分物化性能差异,实现分步降解的效果;高温热处理支架管中膜组分在两种尿液环境中以不同速度碎裂,与纤维组分的降解形式有差异;压缩曲线反映"纤-膜"支架管中膜组分的降解程度,而拉伸过程中前后段的曲线则分别反映膜组分碎裂程度及纤维组分的拉伸性能.

The ureteral stents with ＂fiber-film＂ and all fiber structure were fabricated by polyglycolide （PGA） and polyglycolide-co-lactide （PGLA） filaments and with three kinds of heat-treatment processes. The degradation study was conducted in human and artificial urine. The mechanical property and morphology were evaluated on the stents during the degradation. The experimental results show that, the degradation of stent is faster with higher temperature of heat-treatment. The heat-treatment with high temperature can increase the difference of two components＇ physical and chemical performance so as to get the effect of stepwise degradation. The film component on the stent heat-treated with high temperature and degraded in two urine solutions cracks in different rates, which has difference with fiber component on their degradation behavior. The compression curve reflects the degradation of film component on ＂fiber-film＂ stent while the forepart and latter part of tensile curve reflect the degree of fragmentation of film component and tensile property of fiber component respectively.