冠状动脉内血栓抽吸物炎症机制的研究进展

Research progress about inflammatory mechanism of aspirated thrombus from coronary artery

血栓抽吸导管可于置入支架前预抽吸血栓,可显著减少ST段抬高型心肌梗死患者经皮冠状动脉介入术后无复流、慢血流的发生率,改善患者预后。同时,对冠状动脉内血栓抽吸所获样本进行病理分析,也为深入研究ST段抬高型心肌梗死的病理生理过程提供了新途径。随着对冠状动脉内血栓抽吸物研究的不断深入,发现炎症反应起着重要作用,本文就冠状动脉内血栓抽吸物的局部炎症浸润、全身炎症活动及其对预后的影响予以综述。

Thrombus aspiration catheter was used for pre-suction before stent implantation in ST segment elevation myocardial infarction （ STEMI ） patents. The incidence of no reflow and slow flow has obviously decreased in this condition. At the same time,the pathological analysis of coronary thrombus also provides a new idea for the further study of pathophysiology of STEMI. After advanced studies of aspirated thrombus from coronary artery, inflammatory response is found to play an important role. This review is to explicate the local inflammatory response,systemic response and prognosis of aspirated thrombus.