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男性性别决定和分化研究进展

Progress in male sex determination and differentiation
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摘要 性别决定和分化是具有两性潜能的性腺发育为睾丸或卵巢的过程。男性性别决定与分化的过程受多个基因的调控，如果这些基因在性别决定和分化的过程中发生异常，则有可能导致性腺发育异常。男性性别决定基因是最早被发现的与性发育异常有关的基因。近些年来发现SRY同源家族基因-9和成纤维细胞生长因子-9基因与性发育异常关系密切。该文旨在对男性性别决定基因、SRY同源家族基因-9和成纤维细胞生长因子-9基因对男性性别决定和分化的作用进行综述，为进一步认识及诊治男童性发育异常疾病奠定基础。 Sex determination and differentiation mean the process that the bipotential gonads develop into ovaries or testes. There are many genes involved in male＇s sex determination and differentiation. The changes of the regulating genes may lead to disorders of sex development. Sex-determining region Y（SRY） gene was the first discovered gene related to abnormal sexual development. Serval studies have found that SRY-related HMG box 9 （soxg） and fibroblast growth factor 9 （ FGF9 ） are associated with disorders of sex development in recent years. This article aims to provide an review of recent study of the role of SRY, SOX9 and FGF9 in sex determination and differentiation. It will provide a foundation for diagnosis and treatment of genetic disease related with male＇s sex determination and differentiation.
作者 刘庆旭 李嫔
机构地区 上海市儿童医院上海交通大学附属儿童医院内分泌科
出处 《国际儿科学杂志》 2016年第8期635-637,共3页 International Journal of Pediatrics
关键词 性发育异常 基因 疾病 Disorders of sex development Gene Disease
分类号 R726.9 [医药卫生—儿科]
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参考文献19

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国际儿科学杂志
2016年 第8期

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