生物制造手性化学品的科学基础项目立项报告

Project Report of Bio-manufacturing of Chiral Chemicals

生物制造手性化学品是以生物学、化学、工程学及信息学等学科的交叉为手段,以光学纯化学品的高质量合成为目标,以快速、高效、高选择性和绿色为特征,以蛋白结构分析、分子生物学、合成生物学、化学合成和反应工程学及系统工程理论等为手段,为手性化学品的清洁、高效、经济和快速生产提供创造性设计思想和新型科学方法。通过分子理性设计、反应性能强化和制造系统重构,最终实现手性化学品的高效绿色生物制造。

Bio--manufacturing of chiral chemicals uses the cross means of biology, chemistry, engineering and informatics. It focuses on the high quality synthesis of optical pure chemicals, in a quick, efficient, high selective and green way. Based on the analysis of protein structure, molecular biology, synthetic biology, chemical synthesis, reaction engineering and system engineering, it provides creative design thinkings and new scientific methods for the dean, efficient, economic and fast production of chiral chemicals. Through rational design, reaction performance enhancement and reconstruction of manufacturing systems, the efficiency chiral chemicals will be realized.