尼可地尔治疗顽固性心绞痛的临床效果分析

Analysis of the Clinical Effect of Nicorandil Treatment of Refractory Angina Pectoris

目的对尼可地尔治疗顽固性心绞痛的临床效果进行分析。方法整群选取并回顾性分析2015年1月—2016年1月该院收治的105例顽固性心绞痛患者临床资料,根据治疗方法不同设为对照组(47例)和研究组(58例),前者给予常规治疗,后者给予尼可地尔治疗,观察两组治疗前后心绞痛发生、不良反应及心绞痛指标。结果治疗后,两组心绞痛发作次数与持续时间均有所减少,但研究组心绞痛发生次数(2.38±0.52)次/周与持续时间(2.74±0.58)min/次少于对照组(7.89±0.61)次/周、(6.47±0.63)min/次,比较差异均具有统计学意义(P<0.05);研究组出现胃肠道反应、头晕头痛、低血压及面色潮红不良反应发生率显著低于对照组,研究组的总的不良反应情况6.89%低于对照组17.01%,比较差异具有统计学意义(P<0.05)。结论尼可地尔用于治疗顽固性心绞痛能够有效改善心功能指标,减少心绞痛发作次数、缩短持续时间疗效显著。

Objective The clinical effect of nicorandil treatment of refractory angina pectoris were analyzed. Methods Group selection the clinical data of 105 cases of patients with intractable angina pectoris in our hospital from January 2015-January 2016 were retrospectively analyzed, according to the different treatment methods to control group （47 cases） and study group （58 cases）, the former was given conventional treatment, which give nicorandil treatment, observation of treat-ment in the two groups before and after the occurrence of angina, adverse reactions and angina pectoris index. Results After treatment, two groups of angina attack frequency and duration were decreased, but the study group angina frequency （2.38 ± 0.52） times/week and duration of （2.74 ± 0.58） min / times less than that of the control group （7.89 ±0.61） times/week, （6.47±0.63） min/times, poor differences were statistically significant （P〈 0.05）; study group gastrointestinal reactions, hy-potension and dizziness headache, flushing the incidence of adverse reactions was significantly lower than the control group, the study group of the total adverse reaction of 6.89%,17.01% lower than the control group, the difference was statistically significant （P〈0.05）. Conclusion Nicorandil for treatment of refractory angina pectoris can effectively improve the cardiac function indexes, reduce angina attack frequency, shorten the duration of the effect is significan.