左旋氨氯地平联合阿托伐汀钙治疗老年单纯性收缩期高血压的临床研究

Clinical Study of Levamlodipine Besylate Combined with Atorvastatin Calcium in the Treatment of Elderly Isolated Systolic Hypertension

目的探究左旋氨氯地平联合阿托伐汀钙治疗老年单纯性收缩期高血压(Senile Simple Systolic Hypertension,SSSH)的临床疗效。方法方便选取于2014年3月—2015年11月期间来该院就诊的110例SSSH患者分为观察组和对照组各55例,对照组口服2.5 mg的左旋氨氯地平治疗,观察组给予左旋氨氯地平联合阿托伐他汀治疗,观察两组临床症状、血脂和血压水平。结果治疗后,观察组TG(3.0±0.8)mmol/L、TC(5.1±1.0)mmol/L、LDL-C(1.3±0.8)mmol/L低于对照组TG(3.8±1.1)mmol/L、TC(6.5±0.8)mmol/L、LDL-C(2.1±0.8)mmol/L,HDL-C(2.8±0.7)mmol/L高于对照组(2.5±0.5)mmol/L。观察组舒张压(75.3±5.8)mm Hg、收缩压(130.4±5.9)mm Hg、脉压差(61.4±2.4)mm Hg低于对照组舒张压(72.1±4.9)mm Hg、收缩压(133.2±6.8)mm Hg、脉压差(72.6±3.5)mm Hg。结论阿托伐汀钙联合左旋氨氯地平治疗SSSH能显著改善患者的临床症状,降低患者血脂水平。

Objective To study the effect of l-amlodipine combined with Atovaquone Ting calcium in the treatment of el-derly patients with Senile Simple Systolic Hypertension （Senile Simple Systolic Hypertension,SSSH） clinical efficacy. Methods Convenient selection come to my hospital in March 2014 to November 2015 and 110 SSSH patients were divided into two groups and 55 cases in the control group, the control group of levo-amlodipine in the treatment of oral 2.5 mg, ob-server group giving levo-amlodipine combined treatment of atorvastatin, were observed clinical symptoms and blood lipid and blood pressure levels. Results After treatment, observation group, TG （3.0±0.8）mmol/L, TC （5.1±1.0）mmol/L, LDL-C （1.3±0.8）mmol/L than the control group TG （3.8±1.1）mmol/L, TC （6.5±0.8）mmol/L, LDL-C （2.1±0.8）mmol/L, HDL-C （2.8± 0.7） mmol/L than in the control group （2.5±0.5）mmol/L.Diastolic pressure in the observation group （75.3±5.8）mmHg, systolic blood pressure （130.4±5.9）mmHg, the pulse pressure （61.4±2.4）mmHg diastolic blood pressure less than the control group （72.1±4.9）mmHg, systolic blood pressure （133.2±6.8）mmHg, the pulse pressure （72.6±3.5）mmHg, a statistically significant （P〈0.05）. Conclusion Calcium Atovaquone Ting combined with l-amlodipine treatment of SSSH can significantly improve symptoms, reduce the level of serum lipids in patients with.