贝那普利联合苯磺酸左旋氨氯地平治疗原发性高血压临床分析

Clinical Analysis of Benner Pury Combined with Amlodipine in the Treatment of Essential Hypertension

目的探讨贝那普利联合苯磺酸左旋氨氯地平治疗原发性高血压的临床效果。方法方便选取该院2014年1月—2015年1月期间收治的原发性高血患者140例,随机分成观察组和对照组,每组均为70例。对照组采用单一的苯磺酸左旋氨氯地平治疗,观察组在对照组基础上加用贝那普利治疗,观察两组患者治疗前后血压、收缩压、舒张压以及治疗后发生不良反应情况。结果对照组患者治疗总有效率为77.14%,明显低于观察组92.86%,差异有统计学意义(P<0.05);对照组患者平均收缩压(138.62±5.21)mm Hg、平均舒张压(89.12±7.56)mm Hg,明显高于观察组患者的平均收缩压(125.12±5.31)mm Hg、平均舒张压(79.21±6.54)mm Hg,差异有统计学意义(P<0.05);对照组患者发生不良反应为12.86%,明显高于观察组的2.86%,差异有统计学意义(P<0.05)。结论采用贝那普利联合苯磺酸左旋氨氯地平治疗原发性高血压具有显著疗效,能够有效改善患者病情,减少不良反应发生,具有较高的临床应用价值。

Objective To investigate the clinical effect of Benner Pury combined with Levamlodipine besylate in the treat-ment of primary hypertension. Methods Convenient selection 140 patients with primary hypertension in our hospital from January 2014 — Jonuary 2015 were randomly divided into observation group and control group, with 70 cases in each group. The control group using hevamlodipine besylate amlodipine mono therapy, the observation group in the control group based on the use of the Benner Pury treatment, observe two groups of patients before and after treatment of blood pressure, systolic blood pressure, diastolic blood pressure and the occurrence of adverse reactions after treatment. Results The pa-tients in the control group the total effective rate was 77.14%, significantly lower than 92.86%in the observation group, sig-nificant difference （P〈0.05）;control group mean systolic blood pressure （138.62±5.21） mmHg, the average diastolic blood pressure （89.12 ± 7.56） mmHg, significantly higher than the observation group average systolic blood pressure in patients （125.12 ± 5.31） mmHg, the average diastolic blood pressure （79.21± 6.54） mmHg, significant difference （P〈 0.05）; in the control group in incidence of adverse reaction was 12.86%, significantly higher than the 2.86% in the observation group, and the difference is significant （P〈 0.05）. Conclusion Benazepril combined with benzene sulfonic acid levorotatory ammo-nia amlodipine in the treatment of primary hypertension has a significant effect, can effectively improve the patient＇s condi-tion, reduce the occurrence of adverse reactions and has a high value in clinical application.