生物反馈和电刺激治疗非溃疡型间质性膀胱炎/膀胱疼痛综合征

Efficacy of biofeedback and electrical stimulation in the treatment of non-ulcer interstitial cystitis/painful bladder syndrome

目的 ：探讨生物反馈和电刺激治疗非溃疡型间质性膀胱炎/膀胱疼痛综合征（IC/PBS）的疗效。方法 ：选择2015年1月至6月非溃疡型女性IC/PBS患者30例,进行生物反馈盆底肌肉电刺激,每天1次,每次20~30 min,5次为1个疗程。所有患者均随访6个月以上。记录患者治疗前后O’Leary-Sant间质性膀胱炎症状指数（ICSI）评分、间质性膀胱炎问题指数（ICPI）评分、盆腔疼痛和尿急/尿频症状（PUF）评分、24 h排尿次数和平均每次排尿量。结果：治疗后1周及1、3、6个月的症状缓解率分别为76.7%（23/30）、66.7%（20/30）、53.3%（16/30）和23.3%（7/30）;ICSI评分、ICPI评分、PUF评分、24 h排尿次数均显著低于治疗前（P〈0.05）,平均每次排尿量增加,与治疗前比较差异均有统计学意义（P〈0.05）。治疗期间未发生明显不良事件。结论 ：生物反馈电刺激治疗非溃疡型IC/PBS安全、有效,但远期疗效有待进一步观察。

Objective： To evaluate the efficacy of biofeedback and electrical stimulation in the treatment of nonulcer interstitial cystitis/painful bladder syndrome（IC/PBS）. Methods： Thirty female patients with non-ulcer IC/PBS were enrolled from Jan. to June 2015, and were treated by biofeedback and electrical stimulation of pelvic floor muscles once daily for 20 to 30 minutes, five times as a course. All patients were followed-up for more than 6 months. The O＇Leary-Sant interstitial cystitis patient symptom index（ICSI）score, the interstitial cystitis patient problem index（ICPI）score, pelvic pain and urgency/frequency（PUF）patient symptom scale, micturition frequency in 24 hrs and mean volume per void were recorded before and after the treatment. Results： The remission rates of symptoms were 76.7%（23/30）, 66.7%（20/30）, 53.3%（16/30） and 23.3%（7/30）after the treatment for 1 week and the 1st, 3rd and 6th months, respectively. The scores of ICSI, ICPI and PUF, the micturition frequency in 24 hrs were significantly lower than those before the treatment（P0.05）. The average voiding volume increased compared to that before the treatment（P0.05）. No serious adverse event was observed during the treatment. Conclusion： Biofeedback electrical stimulation is safe and effective in the treatment of non-ulcer IC/PBS, but the long-term efficacy should be observed further more..