摘要
目的考察促透皮吸收剂对菌克软膏中硝酸咪康唑透皮吸收的影响,并筛选最佳透皮吸收剂及用量。方法采用Franz扩散池法,以离体裸鼠皮为透皮屏障,HPLC法测定含量,计算累积透皮量。结果累积透皮量检测表明,不同促渗剂的促渗强弱顺序依次为3%氮酮>5%丙二醇>5%油酸>3%薄荷脑>不加促透剂,不同用量的氮酮促渗作用强弱顺序依次为5%氮酮>3%氮酮>1%氮酮>菌克。结论几种促透剂对菌克软膏中硝酸咪康唑均有促透皮吸收作用,其中氮酮的促透效果最好,且5%氮酮的促透效果最为明显。
Objective To study the effects of penetration enhancers on percutaneous permeability of micon- azole nitrate in Junke cream, and to screen for the best transdermal absorption and amount. Methods Franz diffusion cell method was used and isolated nude mice skin was as the percutaneous barrier, the content was detected by HPLC, and the cumulative permeation quantity was calculated. Results The cumulative permeation quantity showed that the rank order of absorbefacient effect in different penetration enhancers was as follows:3 % azone 〉 5 % propylene glycol 〉 5 % oleic acid 〉 3 % menthol 〉 without penetration enhancer;the rank order of absorbefacient effect in different dos- age of azone was as follows : 5 % azone 〉 3 % azone 〉 1% azone 〉 Junke. Conclusion All the penetration enhancer can enhance the transdermal absorption of miconazole nitrate in Junke cream, and the best penetration enhancer is azone,in which,5% azone has the most obvious effect.
出处
《实用药物与临床》
CAS
2016年第8期1011-1014,共4页
Practical Pharmacy and Clinical Remedies