摘要
近年来,药物共晶筛选技术成为改善药物溶解度、稳定性等性质的研究热点。该技术不改变药物分子结构,只是通过分子间作用力改变药物的理化性质,为难溶性药物的研发提供了新途径。共晶是具有新特性的药物组合,可获得知识产权。本文综述了药物共晶筛选技术,为药物共晶的深入研发提供参考。
Recently,the screening technologies of pharmaceutical cocrystals have become a research focus of improving drug solubility and stability. The technique changes medicine properties by intermolecular forces without changing the molecular structure,which provides new ways for the development of the insoluble drug. In addition,the formation of cocrystal gives new properties to drugs and intellectual property rights are effectively protected. This review focuses on screening technique,which provides references for further studies of pharmaceutical cocrystal.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2016年第4期682-687,共6页
Journal of International Pharmaceutical Research
基金
江苏省自然科学基金项目(BK20141094)
江苏省中医药局科技项目(PY201518)
关键词
药物共晶
筛选技术
pharmaceutical cocrystals
screening technologies