奥扎格雷治疗频发短暂脑缺血发作的疗效观察

To observe the curative effect of Ozagrel in the treatment of frequent transient ischemic attack

目的观察奥扎格雷治疗频发短暂脑缺血发作(TIA)的疗效。方法选取频发TIA患者75例,随机分为治疗组38例与对照组37例。对照组采用曲克芦丁治疗,治疗组采用奥扎格雷治疗,观察2组临床效果、TIA停止时间;2组均在治疗前及疗程结束后测定血液流变指标、凝血酶原时间与血小板聚集率等。结果治疗组总有效率为71.1%,优于对照组的37.8%(P<0.05),3d内TIA发作控制率为55.2%,亦明显优于对照组的24.3%(P<0.05)。结论奥扎格雷治疗频发短暂脑缺血发作可在短期内清除或减少发作,阻止病情进展,降低缺血性卒中发生率。

Objective To observe the curative effect of Ozagrel in the treatment of frequent transient ischemic attack. Methods 75 cases of frequent TIA were selected, and randomly divided into treatment group and control group,38 cases and 37 cases. The control group was treated with troxerutin, the treatment group was treated with ozagrel. The clinical effect and TIA stopping time were compared between the 2 groups. The blood rheology indexes, prothrombin time and platelet aggregation rate were measured before and after the course of treatment. Results The total effective rate of the treatment group was 71.1%, better than 37.8 % of the control group （P 〈 0.05 ）. The control rate of 3 D in TIA was 55.2%, which was better than 24.3 % in the control group （P 〈 0.05 ）. Conclusion Ozagrel in the treatment of frequent transient ischemic attack （TIA） can be in the short term clearance or reduce seizure, stop the progress of the disease,reduce the incidence of ischemic stroke.