高危型HPV感染与宫颈病变发生风险分析

Risk Analysis of High Risk HPV Infection and Cervical Lesions

目的通过对比研究的方法分析当TCT≤ASCUS时,人乳头状瘤病毒(HPV)不同亚型在不同级别宫颈上皮内瘤变(CIN)与宫颈癌中的分布及临床意义。方法整群选取2013年1—12月在该院宫颈科门诊行TCT及HPV联合筛查的患者394名,若TCT异常或HPV阳性的患者,同时行阴道镜下行宫颈活检、经病理学诊断确诊。选取TCT≤ASCUS,且单一HPV检测阳性的患者进行分析。使用DNA芯片技术检测宫颈脱落细胞HPV亚型。结果 1分析HPV感染基因型与宫颈病变程度的关系,发现在高级别CIN还是低级别CIN患者中,均是HPV16型(分别占46.46%及43.36%)。2在该研究所有单一HPV感染人群中,HPV16检出率最高(58.22%)。结论 HPV感染尤其是HPV16、18型感染与宫颈病变程度密切相关,即便是TCT正常者,也需要引起临床上的重视。在TCT结果为炎症及ASCUS患者中,HPV58型感染,仍应引起临床的高度重视。

Objective Through the method of comparative study analysis when the TCT is less than or equal to ascus, hu-man papilloma virus （HPV） of different sub type in different grade of cervical intraepithelial neoplasia （CIN） and cervical cancer in the distribution and clinical significance. Methods Group select January 2013 to december 2013 in patients with the cervical clinic of the department of TCT and HPV screening with 394, if abnormal TCT or HPV positive patients. At the same time, colposcopy and cervical biopsy, the pathological diagnosis. Select TCT≤ASCUS, and single HPV positive pa-tients were analyzed. The use of DNA chip technology in the detection of cervical exfoliated cells HPV subtype. Results ①analysis of HPV infection gene type and the severity of cervical lesion, found in high grade CIN or low grade CIN patients are HPV16 accounting for 46.4% and 43.36%, respectively. ②in this study all single HPV infected people, the highest de-tection rate of HPV16 （58.22%）. Conclusion HPV infection, especially HPV16, type 18 infection is closely related with the degree of cervical lesions, even if it is a normal TCT, also need to cause clinical attention. In the TCT results for inflamma-tion and ASCUS patients, HPV58 infection, still should cause clinical attention.