玻璃体腔注射雷珠单抗对湿性年龄相关性黄斑变性患者眼血流动力学的影响

Changes of ocular hemodynamics after intravitreal ranibizumab injection in patients with wet age-related macular degeneration

目的探讨湿性年龄相关性黄斑变性患者经单独玻璃体腔注射雷珠单抗治疗后眼血流动力学的变化。方法纳入20例患者(20眼)。所有患者术前、术后1周、术后4周测量眼动脉、视网膜中央动脉、睫状动脉血流动力学参数指标,包括收缩期峰值流速(PSV),舒张末期血流速度(EDV)及阻力指数(RI),搏动指数(PI)。比较患者不同时间点眼血流动力学参数的差异性。结果注射眼术前,术后1、4周眼动脉、视网膜中央动脉、睫状后动脉的PSV、EDV、RI、PI差异均无统计学意义。同样对侧眼术前,术后1、4周,眼动脉、视网膜中央动脉、睫状后动脉的PSV、EDV、RI、PI差异均无统计学意义。结论单独玻璃体腔注射雷珠单抗不影响湿性AMD患者的眼血流动力学。

Objective To evaluate the changes in retrobulbar blood flow by using color Doppler sonography in patients who had undergone a single intravitreal ranibizumab injection for wet age-related macular degeneration（ wAMD）.Methods 20 wAMD patients（ 20 eyes） who had undergone intravitreal 0. 5 mg ranibizumab injection were enrolled in this study. The ophthalmic artery,central retinal artery and ciliary artery of both eyes of patients were evaluated by color Doppler sonography. Peak systolic velocity（ PSV）,end-diastolic velocity（ EDV）,and resistance index（ RI） and pulsatility index（ PI） values were calculated before injection,and after injection on day 7 and day 30. The differences of ocular hemodynamic parameters were analysed at different time points. Results In a comparison with the pre-injection values of PSV,EDV,RI and PI,the post-injection values at both 1 and 4 week showed no statistically significant difference in ophthalmic artery,central retinal artery and lateral posterior ciliary artery. Similarly,all the same parameters revealed no statistically significant difference in the un-injected healthy felloweyes. Conclusion Intravitreal ranibizumab injection for wAMD does not cause a significant difference in the retrobulbar blood flow in either the injected eye or the felloweye.