摘要
目的探讨玻璃体腔注射康柏西普治疗视网膜静脉阻塞(retinal vein occlusion,RVO)继发黄斑水肿(macular edema,M E)的有效性。方法采用前瞻性连续性非对照的临床病例分析。选择2014年9月至2015年2月就诊的RVO继发ME 30例30眼,其中视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)继发的ME 9例9眼,视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)继发的ME 21例21眼。玻璃体腔注射康柏西普治疗3次,随访6个月,观察最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心凹视网膜厚度(central macular thickness,CM T)。结果 BRVO患眼治疗前及治疗后6个月BCVA分别为(0.77±0.24)log M AR、(0.27±0.19)log M AR,CM T分别为(596.8±139.6)μm、(272.6±29.2)μm,差异具有显著统计学意义(t=4.483,P<0.05;t=7.189,P<0.05);CRVO患眼治疗前及治疗后6个月BCVA分别为(0.87±0.55)log M AR、(0.43±0.2)log M AR,CM T分别为(647.3±163.6)μm、(393.1±121.5)μm,差异具有显著统计学意义(t=2.288,P<0.05;t=7.189,P<0.05)。结论玻璃体腔注射康柏西普是一种治疗RVO继发M E的有效方式。
Objective To explore the effects of intravitreal injection of conbercept for macular edema( ME) secondary to retinal vein occlusion( RVO). Methods A prospective,continuity and uncontrolled clinical case analysis was used. Thirty cases( 30 eyes) with ME secondary to RVO in our hospital from September 2014 to February 2015 were selected,in which 9 cases( 9 eyes) were central retinal vein occlusion( CRVO) and 21 cases( 21 eyes) were branch retinal vein occlusion( BRVO). All cases were treated with intravitreal injection of conbercept for 3 times and followed up for 6 months. Best corrected visual acuity( BCVA) and central macular thickness( CMT) were observed. Results In patients with BRVO,mean BCVA before treatment and 6 months after treatment were( 0. 77 ± 0. 24) log MAR,( 0. 27 ± 0. 19) log MAR,and CMT were( 596. 8 ± 139. 6) μm,( 272. 6 ± 29. 2) μm,respectively,the difference has statistical significance( t = 4. 483,P〈0. 05; t = 7. 189,P〈0. 05). In patients with CRVO,mean BCVA before treatment and 6 months after treatment were( 0. 87 ± 0. 55) log MAR,( 0. 43 ± 0. 2) log MAR,and CMT were( 647. 3 ±163. 6) μm,( 393. 1 ± 121. 5) μm,respectively,the difference has statistical significance( t = 2. 288,P〈0. 05; t =7. 189,P〈0. 05). Conclusion Intravitreal injections of conbercept is effective for ME secondary to RVO.
出处
《山东大学耳鼻喉眼学报》
CAS
2016年第4期105-108,共4页
Journal of Otolaryngology and Ophthalmology of Shandong University