摘要
目的对转化生长因子TGF-β与结缔组织生长因子CTGF在石英导致的肺纤维化过程中的作用进行综述。方法通过查阅国内外与TGF-β、CTGF以及石英致肺纤维化相关的文献资料,分析TGF-β、CTGF在石英所致肺纤维化过程中作用。结果石英暴露可导致TGF-β升高,而TGF-β又通过Smad依赖途径和Smad非依赖途径诱导CTGF的生成。TGF-β启动肺纤维化,并通过产生高水平的CTGF来进一步维持持续的纤维化反应,而CTGF表达增加可能才是石英导致肺纤维化发生发展的中心环节。结论 CTGF在TGF-β的调控下参与了石英所致肺部纤维化的发展与维持。
Objective This paper reviewed the role of transforming growth factor-beta（TGF-beta） and connective tissue growth factor（CTGF） in the process of pulmonary fibrosis induced by quartz.Methods Through consulting the domestic and foreign literature related to TGF-beta,CTGF and pulmonary fibrosis induced by quartz,the role of TGF-beta and CTGF in the process of pulmonary fibrosis induced by quartz was analyzed.Results Quartz exposure could lead to the increase of TGF-beta,and TGF-beta induced CTGF via activation of both Smad-based and non-Smad-based signaling pathways.TGF-beta started the process of pulmonary fibrosis,and high-level CTGF further sustained fibrous reaction.Therefore,the increase of CTGF might be the crucial link in the occurrence and development of pulmonary fibrosis caused by quartz.Conclusion CTGF was associated with the development and maintenance of pulmonary fibrosis induced by quartz in the regulation of TGF-beta.
出处
《公共卫生与预防医学》
2016年第4期76-80,共5页
Journal of Public Health and Preventive Medicine
基金
国家自然科学基金(81402659)
