评价分析肿瘤坏死因子-α和转铁蛋白检测在肺结核诊治中的临床价值

Evaluation and Analysis of Clinical Value of Tumor Necrosis Factor-α and Transferrin in the Diagnosis and Treatment of Tuberculosis

目的：探讨肿瘤坏死因子-α（TNF-α）和转铁蛋白（TRF）检测在肺结核诊治中的临床价值。方法：研究的110例肺结核患者均为医院在2014年8月-2015年8月期间收治,对其治疗前、治疗后6个月与9个月的TNF-α和TRF水平进行检测,并与同期痰标本检验结果进行比较分析,同期选取60例健康体检者作为参照组。结果：观察组伴随痰液内结核分歧杆菌检出数量的增加,其TNF-α和TRF水平也随之升高（P〈0.05）;痰检结果由阳性转为阴性的患者TNF-α和TRF水平在治疗后6个月明显降低（P〈0.05）,治疗后9个月则接近正常水平。结论：肿瘤坏死因子-α和转铁蛋白检测在肺结核诊治中的临床价值显著,有助于明确患者的感染情况与治疗效果。

Objective To investigate the tumor necrosis factor -α （TNF-α） and transferrin （TRF） detection of clinical value in the diagnosis and treatment of tuberculosis. Methods： 110 cases of tuberculosis patients from August 2014 to August 2015 were taken as research objects, the TNF-α and TRF level during its pre-treatment, after six months and after 9 months were examined and were compared with sputum samples during the same period, and 60 healthy cases over the same period were selected as the reference group. Results： TNF-α and TRF levels of the observation group were increases with sputum Mycobacterium tuberculosis（P〈 0.05）; 6 months after treatment, TNF-α and TRF of the patients whose smear results from positive to negative patients was significantly reduced（P〈0.05） ; 9 months after treatment , it is close to normal levels. Conclusion： Clinical value of Tumor necrosis factor -α and transferrin in the diagnosis and treatment of tuberculosis significantly help clear the infection and patient outcomes.