丙型肝炎炎症发生与细胞信号通路异常

Inflammation of hepatitis C and abnormality of cell signaling pathway

丙型肝炎病毒(hepatitis C virus,HCV)感染是引起慢性丙型肝炎的直接原因,炎症的持续发生会导致肝纤维化、硬化甚至是肝癌的出现。炎症发生通常与细胞信号通路异常相关,病毒感染后病毒蛋白干扰宿主细胞正常的信号转导途径,使得促炎和炎症相关分子异常表达,导致炎症的发生。了解HCV感染后炎症发生的分子机制将有助于防止丙型肝炎炎症的恶化,为临床抗病毒治疗提供参考。

HCV infection is the cause of chronic hepatitis C, and the subsequently sustained inflammation can result in liver fibrosis, cirrhosis and hepatic carcinoma. The occurrence of inflammation is usually as- sociated with the abnormal cellular signal transduction. The interaction between viral proteins and the host proteins in signal transduction pathway may lead to unusual cellular expression of pro-inflammatory and in- flammatory molecules. Understanding the molecular mechanism of hepatitis C inflammation is helpful for the prevention of hepatitis C inflammation, and provides the necessary basic data for its therapy.