摘要
G蛋白偶联受体84(GPR84)属于脂肪酸受体,能被中链脂肪酸(C9-C14)激活。人体内GPR84主要表达在骨髓,其次表达在外周白细胞和肺,在生理状态下GPR84表达量较低,炎症刺激(如脂多糖)可诱导GPR84在单核/巨噬细胞中高表达,可知GPR84与炎症有很大关系。许多疾病的发生发展伴随着炎症反应,而GPR84小分子调节剂能调节炎症反应,从而干预相关疾病的进程。本文主要就GPR84与各类疾病的关系,以及GPR84小分子调节剂的研究展开综述。
GPR84 belongs to free fatty acid receptors （FFAR） and it is mainly activated by MCFA （C9-14）. GPR84 is highly expressed in human bone marrow, and to a lesser extent, in the peripheral leukocytes and lungs. In physiological conditions, the expression of GPR84 is low, but it can increase remarkably in mono- cytes/macrophages upon activation by lipopolysaccharide. Several recent studies also showed that GPR84 plays a significant role in inflammation, and GPR84 modulators therefore have potential use in regulating in- flammation. In this review, we summariTe tho re^o~nt ~rl ~^-UOOn ~_a ： J 1 ,
出处
《生命的化学》
CAS
CSCD
2016年第4期548-555,共8页
Chemistry of Life
