整合素:心肌病精准医疗的新靶标?

Integrin:a new target for precision medicine of cardiomyopathy?

心肌病通常与遗传有关,常由单个心肌蛋白突变造成。精准诊治目前是心肌病面临的困境。整合素在心肌细胞机械刺激的传导和感应中起到主要作用。整合素和一些相关的细胞骨架蛋白,能将肌动蛋白同细胞外基质联系起来,并触发细胞内信号途径,引起心肌肥大。本文通过对整合素致心肌肥大机制的深入认识,揭示心肌病精准医疗的新靶标。

Cardiomyopathy is usually associated with genetic mutations,which caused by the single mutation in cardiac protein.Precision diagnosis and treatment of cardiomyopathy are difficult at present.Integrin plays an important role in the conduction and induction of mechanical stimulation in cardiomyocytes.Integrin and a number of related cytoskeletal proteins,can link to actin and extracellular matrix,and trigger the intracellular signaling pathway,which causes cardiac hypertrophy.In this paper,we explore the mechanism about cardiac hypertrophy induced by integrin,and reveal the new target of the precise medical treatment in cardiomyopathy.