父母糖尿病史与中年人群血脂、脂蛋白和载脂蛋白水平关系的研究

Association of parental history of diabetes with serum lipids,lipoproteins and apolipoproteins in middle-aged Chinese

目的：探讨父母糖尿病史与中年人群血脂、脂蛋白和载脂蛋白水平的关系。方法：2010年对来自于我国不同地区的12组35~64岁人群进行心血管病危险因素调查,询问父母糖尿史,并测量身高、体重、腰围以及进行空腹血糖血脂测定。结果：资料完整用于本文资料分析者共计9170例,根据父母的糖尿病史情况,将研究对象分为父母均无糖尿病史者、父母一方有糖尿病史者和父母双方均有糖尿病史者。3组人数分别为8512例、617例和41例。在控制了年龄、性别、文化程度、家庭平均年收入、吸烟、饮酒、体质指数、腰围、收缩压、舒张压、空腹血糖水平等多种因素后,3组间的HDL-C（mmol/L）水平分别为（1.41±0.01）,（1.39±0.01）和（1.31±0.04）（趋势检验P=0.034）;3组间的TG（mmol/L）水平（经对数转换）分别为（0.37±0.01）,（0.38±0.02）和（0.54±0.08）（趋势检验P=0.031）;3组间的apoB（mg/dL）水平分别为（94.5±0.4）,（97.1±0.9）和（100.1±3.2）（趋势检验P=0.074）;3组间的apoB/apoA1比值分别为（0.671±0.003）,（0.697±0.008）和（0.726±0.028）（趋势检验P=0.053）;TC、LDL-C、apoA1、Lp（a）和父母糖尿病史间的关联较弱,3组之间的趋势检验均不具有统计学显著性。结论：父母糖尿病史与中年人群的血脂和载脂蛋白水平之间存在显著的关联,父母双方均有糖尿病者其关联更强,对于父母有糖尿病史者,尤其是父母双方均有糖尿病史者应注意采取健康生活方式并定期进行血脂水平的检测。

Objective：To explore the association of the parental history of diabetes with the serum lipids,lipoproteins and apolipoproteins in middle-aged Chinese.Method：The cardiovascular risk factors data including parental history of diabetes were collected and the serum fasting glucose,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,triglyceride（TG）,lipoprotein Lp（a）,apolipoprotein A1 and B were determined in 12 Chinese subpopulations that located in different parts of the Country and aged 35 to 64years old in 2010.Result：The data of 9170 subjects were used for this analysis.The subjects were divided into three groups depending on whether they had zero,one,or two parents affected with diabetes.For the subjects with zero,one,or two parents affected,the number of subjects was 8512,617 and 41,respectively.The results of ANCOVA showed that,after adjusted for age,sex,education level,average family income,smoking,drinking,body mass index（BMI）,waist circumference,systolic blood pressure,diastolic blood pressure and fasting glucose,for the subjects with zero,one,or two parents affected,the HDL-C（mmol/L）was 1.41±0.01,1.39±0.01,1.31±0.04（Pfor trend=0.034）,respectively;the log transformed TG（mmol/L）was 0.37±0.01,0.38±0.02 and 0.54±0.08（Pfor trend=0.031）,respectively;the apoB（mg/dL）was 94.5±0.4,97.1±0.9and 100.1±3.2（Pfor trend=0.074）,respectively;the apoB/apoA1 was 0.671±0.003,0.697±0.008 and 0.726±0.028（Pfor trend=0.053）,respectively;the association of TC,LDL-C,apoA1,Lp（a）with parental history of diabetes was weak and of no statistical significance.Conclusion：There is a significant association between the individuals＇ parental history of diabetes and the serum lipids and lipoproteins in middle-age Chinese,and the association is stronger for those with both parents affected.