白芍总苷配伍枸杞治疗口腔扁平苔藓患者的疗效评价

Curative Effect of Total Glucosides of Paeony Combined with Wolfberry in the Treatment of Olp

目的:评价白芍总苷配伍枸杞治疗口腔扁平苔藓(OLP)患者临床疗效、不良反应及免疫功能的变化。方法:口腔扁平苔藓患者70例随机分为两组,分别为白芍总苷配伍枸杞治疗组和白芍总苷治疗组,观察、比较两组治疗2个月后的临床疗效、免疫功能的变化及用药期间的不良反应。结果:白芍总苷配伍枸杞治疗组总有效率为88.57%,白芍总苷治疗组总有效率为68.57%,白芍总苷配伍枸杞治疗组疗效显著优于白芍总苷组(P<0.05),不良反应轻(P<0.05);同时白芍总苷配伍枸杞治疗组较白芍总苷治疗组OLP患者的补体C3、C4、CD3+细胞数升高(P<0.05)。结论:白芍总苷配伍枸杞治疗口腔扁平苔藓患者疗效显著,能较好地调节OLP患者的机体免疫状况,不良反应轻微。

Objective：To evaluate the clinical efficacy,the adverse reactions and the changes of the immunity state of OLP patients treated with total glucosides of paeony（TGP）combined with wolfberry.Methods：Seventy OLP patients were randomly divided into two groups：one group with oral TGP capsules and Wolfberry;the other group with oral TGP capsules.The clinical efficacy,the adverse reactions and the changes of the immune function were observed after two months.Results：The total effective rate was 88.57%in the combined group,and the total effective rate was 68.57%in the TGP group.The clinical efficacy was better in the combined group with less adverse reaction（P0.05）.However,the numbers of the C3,C4,CD3＋cells were increased（P0.05）.Conclusion：Per os TGP combined with Wolfberry showed better therapeutic effect,mild adverse reactions,and might regulate the immunity function of OLP patients.