成牙本质细胞表达相关蛋白作用的研究进展

Research Progress of Odontoblasts Related Proteins in Tooth Development and Damage Repairation

成牙本质细胞分泌的蛋白质、基质、生长因子等在牙齿发育和牙髓损伤修复中都起着重要的调节作用。牙本质基质蛋白(DMP1)、牙本质涎蛋白(DSP)、牙本质磷蛋白(DPP)、巢蛋白、clock蛋白、骨黏附蛋白聚糖(OSAD)等在牙本质形成、矿化及牙本质修复等过程中发挥着各自的作用。此外,其中某些蛋白对常染色体隐性低血磷性佝偻病、非矿化组织疾病发病机制的研究具有重要意义。本文就成牙本质细胞表达相关蛋白在牙发育及损伤修复中的作用机制做一综述。

Odontoblasts secreted proteins,matrix,and growth factors play important roles in regulating the tooth development and dental pulp damage repair.Dentin matrix protein（DMP1）and dentin sialoprotein（DSP）,dentin phosphoprotein（DPP）,nest protein,clock proteins,bone adhesion proteoglycans（OSAD）play important roles in the process of dentine formation,mineralization and dentine repair.In addition,some proteins will have important guiding significance for the pathogenesis research of autosomal recessive low blood phosphorus rickets and non mineralized tissue disease.This article aims to explain the role of odontoblasts related proteins in tooth development and damage repairation.