摘要
Toll样受体是架接固有免疫和适应性免疫的桥梁,TLR4是当前研究的热点之一。影响胰岛素抵抗的主要因素有:游离脂肪酸、炎症、氧化应激和内质网应激。胰岛素抵抗早期处于慢性炎症状态,而TLR4与炎症有着密不可分的关系。对TLR4信号通路与胰岛素抵抗相关性进行深入研究,有助于解释胰岛素抵抗的发病机制及病理过程。
Toll like receptors are the bridge of innate immunity and adaptive immunity, and TLR4 is one of the focus in the current research. The main factors that affect insulin resistance include：free fatty acid, inflammation, oxidative stress and endoplasmic reticulum stress. The early stage of insulin resistance in astate of chronic inflammation, and TLR4 is closely related to inflammation. Further study on the correlation between TLR4 signaling pathway and insulin resistance helps to explain the pathogenesis and pathological process of insulin resistance.
出处
《海峡药学》
2016年第8期17-20,共4页
Strait Pharmaceutical Journal
关键词
胰岛素抵抗
游离脂肪酸
炎症
内质网应激
氧化应激
Insulin resistance
Free fatty acid
Inflammation
Endoplasmic reticulum stress
Oxidative stress
