血清高敏C反应蛋白、尿酸与急性心肌梗死早期死亡的相关性研究

Correlation of High Sensitive C-Reactive Protein and Uric Acid in Early Death of Acute Myocardial Infarction

目的：观察急性心肌梗死（AMI）患者血清高敏C反应蛋白（hs-CRP）和尿酸（UA）表达的变化，探讨其与AMI早期死亡的相关性。方法分别测定156例AMI患者血清hs-CRP、UA水平，选择其中28例发病1周内死亡患者为早期死亡组，其余128例患者为非死亡组。比较两组患者血清hs-CRP及UA水平，并对hs-CRP与UA的相关性进行分析。结果 AMI早期总病死率为17.95%，急性非ST段抬高型心肌梗死的早期病死率高于急性ST段抬高型，差异具有统计学意义（23.40% vs.9.68%，P﹤0.05）；AMI早期死亡患者hs-CRP和UA明显高于非死亡组（hs-CRP：29.45±8.48 vs.17.82±5.13 ng/mL，P﹤0.01；UA：436.22±122.53 vs.378.99±108.31μmol/L，P﹤0.05），而且两组患者血清hs-CRP与UA呈显著正相关（P﹤0.05）。结论血清hs-CRP和UA与AMI的发生发展密切相关，联合检测血清hs-CRP和UA有助于对AMI的早期预后评估。

Objective To explore the correlation of high sensitive C-reactive protein （hs-CRP） and uric acid （UA） in early death of acute myocardial infarction （AMI）.MethodsThe serum hs-CRP and UA level were detected in 156 AMI patients. 28 cases who died within 1 week of the onset as early death group, and the remaining 128 patients as non-death group. Serum hs-CRP and UA were compared in two groups and correlation of hs-CRP and UA were analyzed.Results The total early mortality of AMI was 17.95%, the early mortality of acute non-ST segment elevation myocardial infarction was higher than acute ST-segment elevation, the difference was statistically significant （23.40% vs. 9.68%,P﹤0.05）. Serum hs-CRP and UA levels in early death group were signiifcantly higher than those in non-death group （hs-CRP： 29.45±8.48 vs. 17.82±5.13 mg/L,P﹤0.01; UA： 436.22±122.53 vs. 378.99±108.31μmol/L,P﹤0.05）. hs-CRP was signiifcantly positive correlated with UA in two groups （P﹤0.05）.Conclusion High hs-CRP and UA are independent risk factors for AMI. Combined detection has important value for the early prognosis of AMI.