槲皮素抗乳腺癌作用机制的研究进展

Research progress on mechanism of action of quercetin in breast cancer prevention

槲皮素是一种天然黄酮醇类多酚化合物,具有多重生物学活性和药理作用,可以通过雌激素作用及抗雌激素作用、逆转耐药及化疗增敏作用、抑制细胞生长并诱导凋亡、抑制肿瘤细胞的侵袭及转移、抑制肿瘤新生血管生成等方式有效地防治乳腺癌。本文对近年来国内外有关槲皮素抗乳腺癌作用机制的研究进展进行综述。

Quercetin is a polyphenol of natural flavonol,with multiple biological activities and pharmacological effects.It has valid antitumor effects against breast cancer cells through estrogenic and anti-estrogenic effects,reversing drug resistance and increasing chemosensitivity,preventing proliferation of cells and inducing apoptosis,inhibiting tumor cell invasion,metastasis and angiogenesis.In this paper,research progress of action mechanism of quercetin against breast cancer in recent years are reviewed.