哌罗匹隆联合碳酸锂对双相抑郁发作的疗效研究被引量：3

导出

摘要目的观察哌罗匹隆联合碳酸锂对双相抑郁发作的疗效和安全性.方法符合入组标准的门诊患者74例随机分为接受哌罗匹隆联合碳酸锂治疗的哌罗匹隆组和接受碳酸锂治疗的碳酸锂组,均维持8周治疗,并分别于治疗2、4、8周末用汉密尔顿抑郁量表（HAMD-17）评分、副反应量表（TESS）进行疗效评价及安全性评价.结果治疗2、4周末,哌罗匹隆组和碳酸锂组HAMD-17评分较基线期降低,但哌罗匹隆组较碳酸锂组减少更为明显,对比差异有统计学意义（P〈0.05）,显示哌罗匹隆组较碳酸锂组起效更快;治疗8周末,两组HAMD-17评分、TESS评分对比无统计学差异（P〉0.05）,两组有效率对比也无差异（P〉0.05）.结论哌罗匹隆联合碳酸锂治疗与单用碳酸锂治疗双相抑郁发作两者疗效相当,但在快速起效方面,哌罗匹隆组优于碳酸锂组.

作者申璎谢光平

机构地区江西省赣州市第三人民医院

出处《中华临床医师杂志（电子版）》 CAS 2016年第11期208-209,共2页 Chinese Journal of Clinicians(Electronic Edition)

关键词哌罗匹隆碳酸锂双相障碍抑郁发作

分类号 R971.41 [医药卫生—药品]

引文网络
相关文献

参考文献3

1汪春运.不典型抗精神病药物的相互作用[J].四川精神卫生,2010,23(3):181-185. 被引量：16
2涂继莹,左笑丛,李焕德.非典型抗精神病药——哌罗匹隆[J].中国临床药理学杂志,2007,23(2):157-160. 被引量：25
3刘荣,宫媛,贺纳斯,邹华根,李红政.哌罗匹隆对帕罗西汀抗抑郁增效作用的研究[J].华南国防医学杂志,2013,27(6):403-405. 被引量：4

二级参考文献39

1Spina E,Scordo MG,D'Arrigo C.Metabolic drug interaction with new psychotropic agent[J].Fundamental & Clinical Pharmacology,2003,17(4):517-538.
2Wójcikowski J,Pichard-Garcia L,Maurel P,et al.The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes[J].Eur Neuropsychopharmacol,2004,14(3):199-208.
3Fleming J,Chetty M.Psychotropic drug interactions with valproate[J].Clin Neuropharmacol,2005,28(1):96-101.
4Kelly DV,Beique LC,Bowmer MI.Extrapyramidal symptoms with ritonavir/indinavir plus risperidone[J].Ann Pharmacother,2002,36(8):827-830.
5Arold G,Donath F,Maurer A,et al.No relevant interaction with alprazolam,caffeine,tolbutamide,and digoxin by treatment with a low-hyperforin St John's wort extract[J].Planta Med,2005,71(4):331-337.
6Spigset,O.Effects of comedication on the serum levels of aripiprazole:evidence from a routine therapeutic drug monitoring service[J].Pharmacopsychiatry,2007,40(3):107-110.
7Barkin RL.Zolpidem extended-release:a single insomnia treatment option for sleep induction and sleep maintenance symptoms[J].Am J Ther.2007,14(3):299-305.
8Yoshino T, Nisijima K, Shioda K, et al. Perospirone, a novel atypical antipsychotic drug, potentiates fluoxetine - induced increases in dopamine levels via multireceptor actions in the rat medial prefrontal cortex [J]. Neurosci Lett, 2004; 1:16 -21.
9Mizuno Y, Komuro S, Kanamaru H. Distribution of perospirone to me -lanin in pigmented rats [ J ]. Eur J Drug Metabol Pharmacokinet ,2003;28:73 - 79.
10Shimakura J, Tani N, Mizuno Y,et al. In vitro drug -drug interactions with perospirone and concomitantly administered drugs in human liver microsomes [J].Eur J Drug Metabolism Pharmacokinet, 2003 ; 28 : 67-72.