萎胃灵1号对慢性萎缩性胃炎癌前病变患者中医证候及病理组织学的影响

Effects of WeiWeiLing No.1 on TCM Syndromes and Histopathology of the Patients with Precancerous Lesions of Chronic Atrophic Gastritis

目的:探讨萎胃灵1号对慢性萎缩性胃炎癌前病变患者中医证候及病理组织学的影响。方法:慢性萎缩性胃炎癌前病变患者61例饭前半小时温开水送服萎胃灵1号,3粒/次,3次/d。脾虚气滞证加用化瘀消痞汤加减治疗,肝胃不和证加用疏肝和胃汤,中焦虚寒证加用温中愈溃汤,胃阴不足证加用枳壳益胃汤,脾胃湿热证加用三仁汤,3个月为1个疗程。结果:慢性萎缩性胃炎癌前病变患者中医证型主要为脾虚气滞证,占42.62%;萎缩的病理改善总有效率为85.25%。结论:该病的基本病机为"脾胃虚弱,元气不足,痰瘀互阻,胃络血瘀",治疗主要以"健脾益气,理气祛湿,活血通络"为大法。

Objective： To explore the effects of WeiWeiLing No. 1 on TCM syndromes and histopathology of the patients with precancerous lesions of chronic atrophic gastritis （CAG）. Methods： All 61 patients of precancerous lesions of CAG took WeiWeiLing No. 1, three pills each time, three times per day, taking with warm water in half an hour before the meal. Besides WeiWeiLing No. 1, The patients of spleen deficiency Qi stagnation pattern were treated with modified HuaYu XiaoPi Tang, the patients of liver-stomach disharmony with ShuGan HeWei Tang, the patients of middle energizer deficiency-cold pattern with WenZhong YuKui Tang, the patients of stomach-yin deficiency pat- tern with ZhiQiao YiWei Tang, the ones of spleen-stomach damp-heat pattern with SanRen Tang, three months were one course of the treatment. Results： TCM syndrome of the patients with precancerous lesions of CAG was spleen deficiency and Qi stagnation pattern, and it occupied 42.62%; total effective rate of atrophy pathological improve- ments was 85.25%. Conclusion： Basic pathogenesis of precancerous lesions of CAG is ＂spleen-stomach deficiency, insufficiency of promordial Qi, intermingled phlegm and stasis, blood stasis of stomach collateral＂, and therapeutic method is ＂invigorating spleen and Qi, regulating Qi and eliminating dampness, promoting blood circulation and freeing the collateral＂.